The Carthusian way of life in the Chartreuse de Valbonne spanned seven centuries - centuries which didn't escape the waves of history.

So through bad times and good, throughout successive demolitions, restorations and embellishments, the Carthusian monks remained faithful to this place, which they only left for good in 1901, when the Combes law forced them into exile.

From then on, the Chartreuse de Valbonne knew difficult times, until August 18, 1926. On that day, in Uzes, the pastor Philadelphe Delord, a former missionary in New Caledonia, and Director of the A.S.V.M.T., the "Association de Secours aux Victimes des Maladies Tropicales " (Association for the Treatment of Victims of Tropical Diseases), bought the Carthusian monastery with funds proffered by an American missionary society (American Mission to Lepers). This organization was itself directed by a friend of Philadelphe Delord, Doctor Justin ABBOT, who had dedicated his life to helping lepers. It was a veritable act of faith which permitted pastor Delord to found the association and to create this "House of Welcome", so dear to his heart, in this beautiful monastery.

The sanatorium of Valbonne was officially recognized by the Ministry of Health which granted it the indispensable approvals to function legally within the framework of the laws on hospitals. The first leper arrived in Valbonne on August 28, 1929.

In the 1960's treatments for leprosy began to prove their effectiveness. Thanks to advances in medical treatment, it was no longer necessary to hospitalize patients. Leprosy no longer required quarantine, as all risk of contagion was excluded after the first treatment. The association wished to maintain the service of leprology until the last patient, but it was then necessary to search for a new orientation.

In 1975 the association established a psychiatric care center in the Carthusian monastery, which was dedicated to re-insertion and occupational rehabilitation.

  
In 1992 it created therapeutic apartments in Pont-Saint-Esprit and a Help-Through-Work center in the monastery. In 1995, it opened a mental health center and housing for workers of the Help-Through-Work center in the hamlet of Ventabren, in Pont-Saint-Esprit.

In 2001 a major plan for the reorganization of activities was approved by trustee authorities. The plan calls for the reorganization and decentralization of the health care activities, and increasing the capacity of the social welfare structures.